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Death, aging, reconstruction (part 1) - diet

 

I would like to raise a question: Is Rebuilding achievable and how to approximate it? This is just my own judgment about achievable procedures. I used a variety of techniques based on a theory. As bizarre as it sounds some of those techniques and procedures might in point of fact worked.

There are a number of hundreds theories of aging. New and old ones. Atypical authors classify them differently.

I would apportion all those theories into 2 groups :

1. Theories of Decline from exterior cause. "Wear and tear". Concept of free radicals destruction is most fashionable at acquaint with time. Antioxidants are painstaking a cure. Remuneration of caloric restriction are often explained by that theory. The guess has good objective assistance in methodical literature. Other theories of this group built-in changes of bacteria in the gut, radiation and accrual of mutations all through life of an individual, etc. - many more of those theories were discussed in the XX century. 2. In-house clock - theories.

I would allocate the "internal clock" theories into 2 more subgroups: 1. Inner clock on the level of cell. Telomeres shortening is the most discussed in copy at present. 2. Inner clock on the level of organism. Augmentation hormone changes was a fresh case of discussion.

Authors are customarily very guarded and objective in methodical literature. Telomeres are commonly discussed in association with "immortal" canker cells. Caloric restriction is discussed as a mean of durability (not rebuilding per se). Level of development hormone (GH) or insulin-like development dynamic drops in aged persons.

Mass media speculates wider: telomeres re-establishment - achievable immortal life, cyst hormone will renew you, etc.

Original controlled studies commonly do not speculate about this. In no way for case drop of GH level in elderly means that just generous it back will make you young again.

Scientific journalism on the odd occasion argue "Rejuvenation" as it is. Authors customarily talk about "longevity". This is very another story. Permanence in a wheelchair is very apparent from a youth before a live audience soccer. One proven approach to reach long life is caloric restriction. Often they say it is the only proven technique. Using antioxidants as a approach to prolong life is in the same category. To put simple, the Guess says: sustenance construct food of rust - peroxides, etc. These foodstuffs dent DNA, proteins, etc. Cell ages. Caloric restriction switches metabolic pathways. There are less free radicals. Hence longevity. Antioxidants work in comparable way - they cut off free radicals. A further speculation is that caloric restriction early at young age delays reproductive age in animals and this slows down biological clocks and prolongs life until an background with high nourishment contribute is found. Animals look small and undeveloped.

Caloric restriction appreciably (25%-100% and more) prolonged life in worms, flies, spiders, rats, mice, etc. Experiments on monkeys and humans are under way and will take decades.

Well, it is all good in experiments and theories. Some argue: why in this case prisoners of concentration camps do not live longer. An added illustration came from "Scientific American" - a anyone had caloric restriction of amazing 20 years or more - no appearance - he just looks like very thin famished being of 50 years. Examples of contradictory attitude also exist (tribes or groups with low food eating or high antioxidants drinking have more centenarians than all-purpose population). Maybe you especially need to start at 10 years of age, look skin-and-bone and weak for the whole life and live to 100 years, receiving to your teenage years at 25. Antioxidants also bring many controversy. Vitamin E did not show many profit all the same it was a big hope for prevention of many diseases of old age. And so on. Today there are big trials that challenge the theory. Tomorrow - great experiments that back up the theory, at least partially. Many big trials and experiments are in print in chief journals - Science, Nature, PNAS, New England JM, JAMA, etc.

One bias for caloric restriction conduct experiment in my judgment is following. Rats live in cage 30cmX60cm for their whole life. There are at least five rats or 20 mice. They live combine years and die. At some point in the experiments they are celebrities when they live 5 years - some lucky ones. The Food is a balanced mixture of nutrition. Caloric restriction is - 60% of their common meal. They almost don't move - there is no space in cage. As a rule they sleep whole day. A little bit they fight and mate. They live in those situation at Yale, at Med U of South Carolina, at Russian State Health Academe and I think in all places else. To balance our fellow humans we would place 10 ancestors on area of 20 agree metres (200 sq. feet) for 50 years in a row, feeding them with what they want but all the same - let say junk food from McDonalds.

I bring to mind my cat (who was incompletely wild) stole meat and ate until it in progress to vomit. He frequent it many times when he was able to steal some steak or whatever. The same happens in wild - lions have maybe one flourishing hunt out of ten. When they catch a prey, they eat like crazy. Much more than they can digest at the moment. So it looks like there is an instinct. Eat as much as possible. This is not a joke - 60% of associates in western countries are overweight. Plentiful high calorie food and lack of activity. It does not seem that for these ancestors any in-house device restricts food consumption. Applying this back to rats, we can see that what is painstaking conventional drinking - "ad lib" - maybe in reality big overfeeding of the animals in these cages.

In this case 60% of caloric restriction would be just what rats need, just what the calories they spend in lazy, everyday daily life. So called "control", "normal" rats - that fed as they customarily fed might be compared for fat heavy humans. They consume junk food. They prone to the bunch of diseases of corpulence and low activity. Heart diseases, strokes, assortment of cancers, arthritis, etc.

In this case all the hype about caloric restriction would just be brought to the affair of mere balancing diet and commotion in so called "calorie-restricted animals". I haven't seen any conversation of this problem. I might be wrong. This is why I use caloric restriction for myself. I did not work with worms and spiders. But my guess would be that they all are also in false consistent conditions. "Control" worms might be also overfed. To put rats into superior cages (to augment doings in check group and consider calories and catabolism) would be incredibly expensive.

Even at acquaint with setting for the reason that of "animal lovers" and bunch of other policy and considerations (e. g. sterile conditions), the price of bodily housing is sky-high.

You would say animals in wild would live longer since they calculate action and consumption. Well, in recent times I read that life span of animals in wild is shorter than animals in captivity. Accurate me if I am wrong: pandas live 15-20 years in character and 20-30 in zoos, bears 20-25 in characteristics and 30-40 in captivity. Development has a variety of payback - vaccinations, good checkup care, more or less good hygiene. So just affecting into wild situation wouldn't make you younger or allow to live longer.

Now, to chat about renewal procedures, I would need to talk about aging first. In this case Reconstruction could be measured as problem of aging (deterioration). Durability is atypical story - it is prolonged life span. Renewal by all accounts be supposed to lead to longevity. But long life is not equal to Rejuvenation. Aging leads to Death eventually. It is easier to converse from that end.

All in black and white here is just plain speculation, take it with a grain of salt.

- constant in Part 2

About The Author

Aleksandr Kavokin, MD,PhD

http://www. geocities. com/aging_rejuvenation/

http://www. geocities. com/usmle_test

aging_rejuvenation@yahoo. com


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